Against the wall

Cell Biology: Up Against the Wall

Lignin is deposited in precise patterns in some cell types. Two recent papers provide insights into how this is achieved in the Casparian strip of the root endodermis where a discrete band of lignin is crucial to regulating the passage of water and solutes.

Up Against the Wall: Primal Therapy and 'the Sixties'

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

Fungal β-1,3-glucan glucanosyltransferases are glucan-remodeling enzymes that play important roles in cell wall integrity, and are essential for the viability of pathogenic fungi and yeasts. As such, they are considered possible drug targets, although inhibitors of this class of enzymes have not yet been reported. Herein we report a multidisciplinary approach based on a structure-guided design ...

Excited Random Walk against a Wall

We analyze randomwalk in the upper half of a three dimensional lattice which goes down whenever it encounters a new vertex, a.k.a. excited random walk. We show that it is recurrent with an expected number of returns of √

Up against the wall: is yeast cell wall integrity ensured by mechanosensing in plasma membrane microdomains?

Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summari...